piperine
3 interactions related to piperine
curcumin + piperine
Piperine (black pepper extract) substantially increases how much curcumin your body absorbs.
turmeric + black pepper
Piperine, the active alkaloid in black pepper, slows the gut and liver enzymes that normally inactivate curcumin (the main bioactive in turmeric). Taking the two together substantially increases how much curcumin reaches the bloodstream, which is why piperine is one of the most common absorption enhancers in turmeric supplements. The same enzyme effect can also raise levels of some prescription drugs, so concentrated daily supplement doses warrant a pharmacist check for people on chronic medications.
black pepper + propranolol
Piperine, the active alkaloid in black pepper, can inhibit intestinal P-glycoprotein and several liver enzymes that normally limit how much propranolol reaches the bloodstream. A small human study found that concentrated piperine raised propranolol's blood levels, so a stable dose may behave like a somewhat higher one, slightly amplifying its blood-pressure and heart-rate effects. Culinary pepper is not the concern; concentrated piperine supplements are.