1 interaction related to phenoconversion
CBD inhibits CYP2C19, one of several enzymes that help break down sertraline, so adding CBD can raise sertraline exposure. A single published case report describes low sodium (hyponatremia) and cognitive decline in an older intermediate-metabolizer patient who added over-the-counter CBD to long-standing sertraline. The evidence is limited to this one report, so treat it as a reason for caution and prescriber discussion rather than a strong contraindication.
