pde5 inhibitor
4 interactions related to pde5 inhibitor
beetroot + vardenafil
Vardenafil blocks PDE5 and prolongs nitric oxide signaling. Beetroot is a major dietary source of nitrate that the body converts to nitric oxide, so concentrated beetroot products can add to vardenafil's blood pressure lowering effect.
grapefruit + sildenafil
Sildenafil is metabolized primarily by CYP3A4. Grapefruit juice inhibits intestinal CYP3A4 and modestly increases sildenafil AUC by about 23 percent while delaying peak concentration, which can worsen the headache, flushing, dizziness, and hypotension typical of PDE5 inhibitors.
beetroot + sildenafil
Beetroot is high in dietary inorganic nitrate that the body converts to nitric oxide, the same vasodilator pathway amplified by PDE5 inhibitors like sildenafil. While organic nitrate drugs (not dietary) are the formal contraindication, large doses of beetroot juice can meaningfully lower blood pressure and may add to sildenafil's vasodilatory effect.
beetroot + tadalafil
Tadalafil inhibits PDE5 for up to 36 hours, prolonging the vasodilatory effect of any nitric oxide pathway activation. Beetroot's dietary nitrate becomes nitric oxide in the body and can add to tadalafil's blood pressure lowering, particularly with concentrated beetroot shots or supplements.