pde5 inhibitor
4 interactions related to pde5 inhibitor
grapefruit + sildenafil
Sildenafil is broken down mainly by the gut and liver enzyme CYP3A4. Grapefruit juice contains furanocoumarins that block intestinal CYP3A4, modestly raising sildenafil exposure and delaying its peak. This can amplify the headache, flushing, dizziness, and transient blood-pressure drop that are typical of PDE5 inhibitors.
beetroot + vardenafil
Vardenafil blocks PDE5 and prolongs nitric oxide signaling. Beetroot is a major dietary source of nitrate that the body converts to nitric oxide, so concentrated beetroot products can add to vardenafil's blood pressure lowering effect.
beetroot + sildenafil
Beetroot is rich in dietary inorganic nitrate, which the body converts to nitric oxide, the same blood-vessel-relaxing pathway that sildenafil (a PDE5 inhibitor) amplifies. The formal contraindication on sildenafil is for organic nitrate drugs, not food, but concentrated beetroot juice and nitrate supplements can lower blood pressure enough that combining them with sildenafil may add to its blood-pressure-lowering effect. This is a mechanism-based caution rather than a documented danger.
beetroot + tadalafil
Beetroot's dietary nitrate is converted in the body to nitric oxide, which relaxes blood vessels and modestly lowers blood pressure. Tadalafil is a long-acting PDE5 inhibitor that prolongs the same nitric-oxide signal. Concentrated beetroot products taken alongside tadalafil can add to its blood-pressure-lowering effect. Whole-food amounts of beets are generally not a concern.