passionflower
2 interactions related to passionflower
clonazepam + passionflower
Passionflower contains constituents that bind GABA-A receptors and may enhance the binding activity of benzodiazepines at those receptors. Combined with clonazepam, the effect is additive central nervous system depression and increased sedation.
clonazepamklonopinpassionflowerpassiflorabenzodiazepinegabasedationherbal interaction
passionflower + lemon balm
Passionflower (Passiflora incarnata) contains flavonoids that act as positive modulators at the GABA-A receptor benzodiazepine site, while lemon balm (Melissa officinalis) inhibits GABA transaminase, the enzyme that breaks down GABA. The two herbs raise GABAergic tone through complementary mechanisms - one boosts receptor activity, the other extends GABA's half-life - which is the basis for several traditional anxiolytic and sleep formulas.
passionflowerlemon-balmgabaanxietysleepherbalsynergymelissa-officinalis