1 interaction related to paroxetine
Paroxetine is an SSRI with potent serotonin reuptake inhibition; St. John's wort independently inhibits serotonin reuptake and induces CYP3A4 and P-glycoprotein. The combination can precipitate serotonin syndrome and is among the most frequently reported SSRI plus St. John's wort interactions in published case series.