p2y12
2 interactions related to p2y12
clopidogrel + ginkgo
Clopidogrel blocks the platelet P2Y12 ADP receptor, while ginkgo biloba inhibits platelet-activating factor through a separate pathway. A controlled healthy-volunteer study found no measurable added platelet inhibition, but case reports and an observational analysis link the combination to bleeding. The realistic concern is a modest, additive bleeding risk, most relevant in older patients and those also taking aspirin.
clopidogrel + garlic
Clopidogrel blocks the platelet P2Y12 ADP receptor to prevent clots. Concentrated garlic supplements also have a mild antiplatelet effect through sulfur compounds such as allicin and ajoene. Taken together, the antiplatelet effects can add up and may modestly raise bleeding risk, especially before procedures. Culinary garlic in food amounts is not a meaningful concern.