oxidative stress
3 interactions related to oxidative stress
smoking + vitamin c
Smoking increases oxidative stress and accelerates the body's turnover of vitamin C, leaving smokers with consistently lower blood and tissue levels of ascorbic acid than non-smokers eating the same diet. Because of this, expert nutrition bodies recommend that people who smoke aim for a higher daily vitamin C intake than non-smokers.
nac + glutathione
NAC (N-acetylcysteine) supplies cysteine, the rate-limiting building block the body uses to make its own glutathione, while supplemental glutathione adds to the existing pool. Both support antioxidant defense, and the pairing is generally well tolerated. Human trial evidence for raising glutathione comes mainly from NAC (often with glycine, as GlyNAC), not from combining NAC with oral or liposomal glutathione, and no study has shown the pair works better than either one alone.
vitamin e + selenium
Vitamin E and selenium are complementary antioxidants. Selenium is the cofactor for glutathione peroxidase, which clears lipid peroxides and spares vitamin E, while vitamin E intercepts free radicals in membranes and reduces the demand on the selenium-dependent enzyme. The partnership is well established in animal and mechanistic studies; clinical benefit of the combination in people is more limited.