overdose
5 interactions related to overdose
alcohol + alprazolam
Alcohol and alprazolam (Xanax) both depress the central nervous system through GABA-A receptor potentiation, producing additive sedation, profound respiratory depression, and impaired psychomotor function. The combination significantly increases risk of overdose death, even at moderate doses of each substance.
alcohol + diazepam
Diazepam (Valium) and alcohol are both GABA-A receptor positive allosteric modulators, producing additive and supra-additive CNS depression with profound risk of respiratory depression, coma, and death. Diazepam's long half-life and active metabolites extend the window of dangerous interaction far beyond the dosing interval.
alcohol + tramadol
Tramadol combined with alcohol produces additive CNS and respiratory depression, and the combination significantly lowers the seizure threshold, increasing the risk of convulsions, serotonin syndrome, and overdose death. Tramadol has unique serotonergic and noradrenergic activity that compounds alcohol's effects beyond what occurs with pure opioids.
alcohol + codeine
Codeine combined with alcohol produces additive CNS and respiratory depression, with risk of fatal overdose particularly elevated in CYP2D6 ultra-rapid metabolizers who convert codeine to morphine rapidly. The combination also increases sedation, impaired judgment, and the risk of accidents.
alcohol + oxycodone
Combining alcohol with oxycodone causes additive central nervous system and respiratory depression, dramatically increasing the risk of fatal overdose, sedation, and impaired breathing. Alcohol can also accelerate the release of oxycodone from extended-release formulations, causing dangerous spikes in blood levels.