osteocalcin
2 interactions related to osteocalcin
vitamin d3 + vitamin k2
Vitamin D3 increases calcium absorption and stimulates production of vitamin K-dependent proteins (osteocalcin, matrix Gla protein) that require vitamin K2 to be activated. Taking the two together is a common, well-tolerated pairing that supports bone health. A separate, established interaction matters here: vitamin K2 reduces the effect of warfarin and other vitamin K antagonists.
vitamin d3vitamin k2mk-7synergybone healthcalciumarterial calcificationosteocalcin
vitamin k2 + calcium
Vitamin K2 activates osteocalcin and matrix Gla protein, two proteins that bind calcium and help direct it into the bone matrix while keeping it out of arterial walls. Taking calcium alongside adequate vitamin K2 supports bone health; the two nutrients work together rather than competing.
vitamin k2calciumsynergybone healthosteocalcinmatrix gla proteinmk-7arterial calcification