osteoarthritis
3 interactions related to osteoarthritis
curcumin + ginger
Curcumin and ginger both inhibit NF-kB and COX-2 signaling, but ginger also independently blocks 5-lipoxygenase and contains gingerols and shogaols that suppress prostaglandin and leukotriene synthesis. A randomized trial of a turmeric-black pepper-ginger combination showed efficacy comparable to naproxen for chronic knee osteoarthritis pain.
curcumin + boswellia
Curcumin inhibits NF-kB and dampens COX-2 transcription while boswellic acids (particularly AKBA) selectively block 5-lipoxygenase and leukotriene synthesis. Together they suppress two non-overlapping arms of the inflammatory cascade, giving better symptom relief in osteoarthritis than either alone.
msm + glucosamine
MSM (methylsulfonylmethane) provides bioavailable sulfur required for the synthesis of glycosaminoglycans and connective tissue, which complements glucosamine's role as a substrate for proteoglycan production. A 12-week randomized trial in knee osteoarthritis found the combination of MSM plus glucosamine produced greater reductions in pain and swelling than either supplement alone.