one-carbon metabolism
2 interactions related to one-carbon metabolism
vitamin b6 + vitamin b12
Vitamin B6 (as pyridoxal 5'-phosphate) and vitamin B12 (as methylcobalamin) act as complementary coenzymes in one-carbon metabolism: B12 helps remethylate homocysteine back to methionine, while B6 routes excess homocysteine down the transsulfuration pathway to cysteine. Together they keep blood homocysteine within a healthier range than either nutrient does alone.
vitamin b6 + folate
Vitamin B6 and folate work in tandem within one-carbon metabolism: folate (as 5-MTHF) donates a methyl group to remethylate homocysteine, while B6 (as PLP) is the cofactor for serine hydroxymethyltransferase and cystathionine beta-synthase, supporting both the folate cycle and the transsulfuration route that disposes of excess homocysteine.