omega-3
15 interactions related to omega-3
omega-3 + vitamin d
Fat from omega-3 supports absorption of the fat-soluble vitamin D
apixaban + fish oil
Apixaban is a direct factor Xa inhibitor that raises bleeding risk on its own. Omega-3 fatty acids in fish oil have a mild antiplatelet effect that can theoretically add to that risk. A large 2024 systematic review and meta-analysis found that typical supplement-level omega-3 intake did not significantly raise bleeding risk, with only a small absolute increase seen at very high, prescription-strength doses. Standard fish oil is generally compatible with apixaban when the prescriber is aware, while high-dose omega-3 should be cleared with a clinician.
rivaroxaban + fish oil
Omega-3 fatty acids in fish oil have a mild antiplatelet effect, slightly shifting platelet thromboxane production and modestly lengthening bleeding time. Rivaroxaban blocks Factor Xa to reduce clotting. The two act through different pathways, so the combination is additive in theory, but clinical evidence suggests the real-world bleeding effect is small. A large randomized trial found no increase in bleeding even with high-dose fish oil.
aspirin + fish oil
Omega-3 fatty acids in fish oil mildly reduce platelet aggregation, which in theory adds to aspirin's antiplatelet effect. In practice, clinical studies have not found a clinically significant increase in major bleeding when standard fish oil is combined with aspirin.
phosphatidylserine + omega-3
Phosphatidylserine and omega-3 fatty acids (especially DHA) are both core structural components of neuronal membranes, and a PS-DHA form mirrors the way the two naturally occur together in brain phospholipids. In older adults with subjective memory complaints, supplementing the pair has shown modest, mostly subgroup-level improvements in memory measures, though the strongest single figures come from small, uncontrolled studies and the placebo-controlled evidence is weaker than the synergy is sometimes presented to be.
omega-3 + curcumin
Omega-3 fatty acids (EPA and DHA) and curcumin lower inflammation through complementary pathways — omega-3s remodel cell membranes and generate specialized pro-resolving mediators, while curcumin inhibits NF-kB and downstream inflammatory cytokine signaling. Human trials in migraine patients show the combination can reduce inflammatory markers more than either alone.
omega-3 + vitamin e
Omega-3 fatty acids (EPA and DHA) are polyunsaturated and highly susceptible to oxidation, which can blunt their cardiovascular and anti-inflammatory benefits. Vitamin E acts as a lipid-soluble antioxidant that helps protect omega-3 fatty acids from peroxidation both during storage and after absorption, which is why most quality fish oils already include a small amount of mixed tocopherols.
flax seeds + warfarin
Flax seeds contain alpha-linolenic acid (a plant omega-3) and soluble fiber, which in theory could nudge warfarin's effect slightly in either direction. In practice the evidence is weak: major interaction databases list no formal flaxseed-warfarin interaction, and the only adverse report is a single confounded case in a patient taking several other supplements. The practical concern is consistency, not the food itself.
chia seeds + warfarin
Chia seeds are rich in the omega-3 fatty acid alpha-linolenic acid (ALA) and in soluble fiber. High, sustained omega-3 intake can mildly inhibit platelet aggregation and may modestly add to warfarin's effect, while the soluble fiber can slow warfarin absorption if the two are taken together. Rare case reports describe enhanced anticoagulation or bleeding with chia and related Salvia species. The practical concern is dietary consistency rather than any single serving.
flaxseed + warfarin
Flaxseed is rich in alpha-linolenic acid, an omega-3 fat with a mild antiplatelet effect, and in soluble fiber that can theoretically bind oral medicines in the gut. Both mechanisms could in principle nudge warfarin's bleeding risk or absorption, but no case of an actual flaxseed-warfarin bleed or INR shift has been documented. The concern is mechanistic and the practical risk from culinary amounts is low.
walnuts + warfarin
Walnuts contain only trace amounts of vitamin K and small quantities of plant-based omega-3 (alpha-linolenic acid). Normal food servings are unlikely to meaningfully shift INR. The standard warfarin principle applies: keep your intake reasonably consistent rather than swinging between none and very large daily portions.
boswellia + omega-3
Boswellic acids inhibit 5-lipoxygenase to reduce pro-inflammatory leukotrienes, while EPA and DHA from omega-3s lower the arachidonic acid available to inflammatory enzymes and serve as substrates for specialized pro-resolving mediators (resolvins, protectins) that help switch inflammation off. The two act at different steps of the same lipid cascade, giving complementary anti-inflammatory coverage. Evidence in joint pain is modest but consistent.
naproxen + fish oil
Naproxen and fish oil both mildly reduce platelet aggregation through separate pathways, so their effects are additive in theory. Pooled clinical-trial data show no meaningful increase in major bleeding at typical doses.
chia seeds + blood thinners
Chia seeds contain plant-form omega-3 (alpha-linolenic acid) and soluble fiber. The omega-3 has a mild, mostly theoretical effect on platelets, and the fiber gel could slow a pill's absorption if eaten at the same time. There is no documented case of chia seeds themselves causing bleeding on warfarin, DOACs, aspirin, or antiplatelet drugs, and human studies of dietary omega-3 do not show added bleeding. The anticoagulant caution often cited comes from a different plant (danshen root), not chia.
warfarin + fish oil
Fish oil may modestly add to bleeding risk when combined with warfarin, though most people on stable doses show little change in INR.