nutrient depletion
4 interactions related to nutrient depletion
oral contraceptives + vitamin b6
Combined oral contraceptives lower pyridoxal 5'-phosphate (the active form of vitamin B6) by altering tryptophan metabolism and increasing B6 turnover. Long-term pill users have lower B6 status than non-users, which may contribute to mood symptoms in some women.
oral contraceptives + magnesium
Several studies have shown that combined oral contraceptive use is associated with lower serum magnesium levels, possibly through estrogen-related shifts in intracellular and extracellular distribution. Low magnesium can contribute to fatigue, premenstrual symptoms, and may modestly elevate venous thromboembolism risk in pill users.
smoking + vitamin c
Smoking increases oxidative stress and accelerates the metabolic turnover of vitamin C, lowering plasma and leukocyte ascorbic acid levels. The NIH Food and Nutrition Board officially recommends that smokers consume an additional 35 mg of vitamin C daily above the standard RDA.
oral contraceptives + folate
Oral contraceptive use is associated with lower plasma and red blood cell folate levels, likely through increased turnover and urinary excretion. Because pregnancies can occur shortly after stopping the pill, low folate stores increase the risk of neural tube defects in any unplanned conception.