nsaid
7 interactions related to nsaid
lithium + ibuprofen
Ibuprofen and other NSAIDs inhibit renal prostaglandin synthesis, which reduces renal blood flow and the kidney's ability to clear lithium. This can raise serum lithium levels, and published case reports describe clinically significant lithium toxicity after an NSAID was started.
alcohol + naproxen
Naproxen is a long-acting NSAID that weakens the stomach's protective lining and blunts platelet function. Adding alcohol stacks several forms of damage on top of each other, and naproxen's long action keeps that interaction window open well beyond the last dose.
ibuprofen + ginkgo
Ibuprofen reduces platelet aggregation through COX-1 inhibition, and Ginkgo biloba has antiplatelet activity through ginkgolide B's antagonism of platelet-activating factor. Used together they can compound the effect on platelets and raise bleeding risk; a fatal intracerebral hemorrhage has been reported in a long-term ginkgo user who started regular ibuprofen.
naproxen + fish oil
Naproxen and fish oil both mildly reduce platelet aggregation through separate pathways, so their effects are additive in theory. Pooled clinical-trial data show no meaningful increase in major bleeding at typical doses.
alcohol + celecoxib
Combining alcohol with celecoxib increases the risk of gastrointestinal irritation, ulcers, and bleeding, and adds stress to the liver and kidneys. Celecoxib's COX-2 selectivity makes it gentler on the stomach than older NSAIDs, but the FDA label still names alcohol as a factor that raises GI-bleeding risk.
alcohol + aspirin
Aspirin and alcohol both damage the gastric lining and impair clotting; used together they raise the risk of upper gastrointestinal bleeding, with risk rising as alcohol intake and aspirin use increase.
alcohol + ibuprofen
Alcohol and ibuprofen each irritate the stomach lining and impair platelet function, and combining them raises the risk of gastrointestinal bleeding and ulcers. Both also stress the kidneys — ibuprofen reduces renal blood flow while alcohol drives dehydration — which can add up to acute kidney injury, especially in older adults or people with existing kidney problems.