1 interaction related to nighttime
Melatonin signals the brain that it is biological night through MT1 and MT2 receptors in the suprachiasmatic nucleus, while magnesium acts as a NMDA antagonist and GABA-A agonist, helping the nervous system actually relax around that signal. A double-blind RCT in nursing home residents with primary insomnia (Rondanelli 2011) found that nightly melatonin 5 mg + magnesium 225 mg + zinc 11.25 mg significantly improved sleep quality, ease of falling asleep, and morning alertness versus placebo.