neural tube defects
2 interactions related to neural tube defects
green tea + folate
Green tea and EGCG inhibit the proton-coupled folate transporter (PCFT) in the small intestine and inhibit dihydrofolate reductase, the enzyme that converts folic acid into its active form. In humans, concomitant green tea reduced folic acid Cmax by about 58% and AUC by about 44%.
green teafolatefolic acidegcgpregnancyneural tube defectsdhfrpcft
oral contraceptives + folate
Oral contraceptive use is associated with lower plasma and red blood cell folate levels, likely through increased turnover and urinary excretion. Because pregnancies can occur shortly after stopping the pill, low folate stores increase the risk of neural tube defects in any unplanned conception.
oral contraceptivesbirth controlfolatefolic acidneural tube defectsnutrient depletionpregnancy planningmethylfolate