metoprolol
5 interactions related to metoprolol
metoprolol + coq10
Metoprolol and other beta-blockers have been shown in laboratory studies to inhibit some CoQ10-dependent enzymes, and long-term beta-blocker therapy is associated with modestly lower CoQ10 levels. There is no absorption clash: CoQ10 does not change metoprolol's blood-pressure or heart-rate effects, and metoprolol does not change how the body uses CoQ10. Whether this depletion meaningfully causes fatigue, or whether CoQ10 supplementation relieves it, rests largely on mechanism rather than interaction-specific trials.
metoprolol + hawthorn
Hawthorn (Crataegus) has mild vasodilatory and heart-supporting effects that can add to the blood-pressure and heart-rate lowering of metoprolol, modestly increasing the chance of low blood pressure, a slow pulse, dizziness, or fainting. The interaction is pharmacodynamic (it happens at the receptor and tissue level), not metabolic, so taking the doses at different times does not prevent it.
metoprolol + melatonin
Metoprolol blocks the beta-1 adrenergic receptors the pineal gland uses to receive its nighttime signal to make melatonin, so it tends to suppress your own melatonin and can contribute to insomnia and vivid dreams. A randomized trial in beta-blocker-treated patients found that low-dose bedtime melatonin improved sleep without interfering with metoprolol's cardiovascular benefits. This is a beneficial, low-concern combination rather than a harmful clash.
cbd + beta-blockers
CBD weakly inhibits CYP2D6, the liver enzyme that clears beta-blockers such as metoprolol, propranolol, and carvedilol, so in theory it could nudge their plasma levels up. CBD also has a mild blood-pressure-lowering effect of its own. Both actions point in the same direction as the beta-blocker, but the CYP2D6 effect is weak and its real-world clinical significance has not been demonstrated in humans.
energy drinks + beta-blockers
Energy drinks and beta-blockers exert opposing cardiovascular effects: beta-blockers slow heart rate and lower blood pressure, while the caffeine and stimulant load in energy drinks pushes the sympathetic system the other way. This can blunt the medication's effect and, in susceptible people, help provoke an arrhythmia.