1 interaction related to methionine synthase
Vitamin B12 and folate are interdependent partners in the methionine cycle: the active form of folate (5-methyltetrahydrofolate) donates a methyl group, while vitamin B12 is the required cofactor for methionine synthase, the enzyme that converts homocysteine back to methionine. Adequate intake of both supports DNA synthesis, healthy red blood cells, and homocysteine balance. Taking high-dose folate alone is the key safety concern, because folate can correct B12-deficiency anemia while allowing nerve damage to progress unnoticed.
