longevity
4 interactions related to longevity
spermidine + resveratrol
Spermidine and resveratrol both induce autophagy but through different upstream mechanisms: spermidine inhibits histone acetyltransferases (lowering histone acetylation), while resveratrol activates the sirtuin SIRT1 (a deacetylase). The two converge on the acetylproteome and have been shown to synergize at low doses for autophagy induction and lifespan extension in model organisms.
resveratrol + quercetin
Quercetin inhibits the sulfotransferase and UDP-glucuronosyltransferase enzymes that rapidly clear resveratrol, prolonging its plasma half-life and free fraction. The two polyphenols also act synergistically on antioxidant and SIRT1-related longevity pathways in cell and animal studies.
nad+ + niacin
Niacin (nicotinic acid) is a vitamin B3 precursor that the body converts to NAD+ via the Preiss-Handler pathway, so pairing oral niacin with direct NAD+ precursors can support cellular NAD+ pools through complementary biosynthetic routes. In a clinical study of mitochondrial myopathy, 1,000 mg/day niacin meaningfully raised muscle and blood NAD+.
fisetin + quercetin
Fisetin and quercetin are structurally related flavonols with overlapping but distinct senolytic and anti-inflammatory mechanisms. Fisetin was identified in a Mayo Clinic screen as the most potent natural senolytic, while quercetin has been clinically tested as part of the dasatinib + quercetin senolytic combination, and the two together broaden the senolytic and antioxidant coverage.