long-term
3 interactions related to long-term
omeprazole + magnesium
Long-term omeprazole use (typically >1 year) is associated with hypomagnesemia, likely via impaired active intestinal magnesium transport through TRPM6/TRPM7 channels. The FDA issued a formal Drug Safety Communication in 2011 warning of serious adverse events including arrhythmia, tetany, and seizures.
famotidine + vitamin b12
Famotidine, an H2-receptor antagonist, reduces gastric acid secretion and thereby impairs cleavage of vitamin B12 from food proteins, which is required for B12 absorption. The effect is less pronounced than with PPIs but is clinically relevant with long-term use.
esomeprazole + vitamin b12
Esomeprazole, the S-isomer of omeprazole, profoundly suppresses gastric acid required to liberate vitamin B12 from food proteins, impairing its absorption with long-term use. Studies confirm a dose- and duration-dependent reduction in serum B12 with chronic PPI therapy.