long-term
3 interactions related to long-term
omeprazole + magnesium
Long-term omeprazole use (typically more than a year, occasionally sooner) can lower body magnesium, likely by impairing active intestinal magnesium transport through the TRPM6/TRPM7 channels. The FDA issued a formal Drug Safety Communication in 2011 warning that prescription proton pump inhibitors can cause hypomagnesemia, with serious cases involving abnormal heart rhythm, muscle spasm (tetany), and seizures.
famotidine + vitamin b12
Long-term daily famotidine lowers stomach acid, which can modestly reduce absorption of vitamin B12 bound to food. Supplemental and fortified-food B12 are unaffected because they do not require stomach acid for absorption.
esomeprazole + vitamin b12
Esomeprazole and other PPIs suppress stomach acid, which can reduce absorption of food-bound vitamin B12 over long-term use; crystalline B12 in supplements is unaffected.