1 interaction related to long half life
Fluoxetine (Prozac) and alcohol both depress the central nervous system, increasing drowsiness, dizziness, and impaired judgment. Fluoxetine and its active metabolite norfluoxetine have unusually long half-lives (1 to 4 days and 4 to 16 days), so alcohol effects can be amplified even when the drink and dose are taken hours apart.