1 interaction related to lifespan
Spermidine and resveratrol both induce autophagy but through different upstream mechanisms: spermidine inhibits histone acetyltransferases (lowering histone acetylation), while resveratrol activates the sirtuin SIRT1 (a deacetylase). The two converge on the acetylproteome and have been shown to synergize at low doses for autophagy induction and lifespan extension in model organisms.