levofloxacin
2 interactions related to levofloxacin
levofloxacin + calcium
Calcium binds (chelates) levofloxacin in the gastrointestinal tract, modestly lowering the antibiotic's peak blood level. Total drug exposure over the dosing interval is largely preserved, so the effect is smaller than with iron, magnesium, or aluminum. Separating the doses by a couple of hours avoids the interaction.
levofloxacincalciumfluoroquinoloneantibioticchelationabsorptionantacidsupplement timing
dairy + fluoroquinolones
Calcium and other metal ions in dairy products bind oral fluoroquinolone antibiotics in the gut, forming poorly absorbed chelate complexes that lower the amount of antibiotic reaching the bloodstream.
dairyfluoroquinolonesciprofloxacinlevofloxacincalciumchelationantibioticabsorption