1 interaction related to l-carnitine
Valproate (valproic acid) depletes carnitine by sequestering it as valproyl-carnitine for mitochondrial transport and by reducing renal reabsorption of free carnitine. Carnitine depletion can impair fatty-acid oxidation and the urea cycle, contributing to raised blood ammonia (hyperammonemia), liver stress, and in some cases encephalopathy.
