kidney injury
3 interactions related to kidney injury
alcohol + naproxen
Naproxen is a long-acting NSAID that weakens the stomach's protective lining and blunts platelet function. Adding alcohol stacks several forms of damage on top of each other, and naproxen's long action keeps that interaction window open well beyond the last dose.
alcohol + celecoxib
Combining alcohol with celecoxib increases the risk of gastrointestinal irritation, ulcers, and bleeding, and adds stress to the liver and kidneys. Celecoxib's COX-2 selectivity makes it gentler on the stomach than older NSAIDs, but the FDA label still names alcohol as a factor that raises GI-bleeding risk.
alcohol + ibuprofen
Alcohol and ibuprofen each irritate the stomach lining and impair platelet function, and combining them raises the risk of gastrointestinal bleeding and ulcers. Both also stress the kidneys — ibuprofen reduces renal blood flow while alcohol drives dehydration — which can add up to acute kidney injury, especially in older adults or people with existing kidney problems.