kidney
5 interactions related to kidney
losartan + potassium
Losartan blocks the angiotensin II receptor, lowering aldosterone and reducing renal potassium excretion in the same way ACE inhibitors do. Concurrent potassium supplementation can drive serum potassium into the hyperkalemic range, with cardiac arrhythmia risk in patients with kidney impairment, diabetes, or heart failure.
lisinopril + potassium
Lisinopril blocks the renin-angiotensin-aldosterone system, reducing aldosterone secretion and impairing the kidneys' ability to excrete potassium. Adding potassium supplements on top of this can push serum potassium into dangerous territory, especially in older adults or those with reduced kidney function.
potatoes + ace inhibitors
Potatoes are very high in potassium (a medium baked potato with skin contains about 900 mg), and ACE inhibitors reduce aldosterone-mediated potassium excretion. Regular large servings of potatoes combined with ACE inhibitors can raise serum potassium, particularly in patients with chronic kidney disease, heart failure, or diabetes.
methotrexate + nsaids
NSAIDs reduce renal blood flow through prostaglandin inhibition and compete with methotrexate at renal tubular transporters, decreasing methotrexate clearance and raising serum levels. The risk is greatest with high-dose methotrexate or pre-existing renal impairment, where the combination can precipitate myelosuppression, mucositis, hepatotoxicity, and acute kidney injury.
salt substitute + lisinopril
Salt substitutes are typically potassium chloride and can deliver hundreds of milligrams of potassium per small serving. Lisinopril and other ACE inhibitors reduce aldosterone and decrease potassium excretion. Combining them can cause clinically significant hyperkalemia, particularly with chronic kidney disease, diabetes, or other potassium-raising drugs.