ketoconazole
2 interactions related to ketoconazole
ketoconazole + st. john's wort
St. John's Wort is a potent inducer of CYP3A4 and P-glycoprotein via PXR activation, which can accelerate the metabolism of ketoconazole and reduce its antifungal blood concentrations and clinical effectiveness.
ketoconazolest johns wortantifungalcyp3a4herbal interactionnizoralazolehypericum
ketoconazole + calcium
Calcium carbonate antacids raise gastric pH above the threshold that ketoconazole needs to dissolve, reducing oral ketoconazole absorption and lowering antifungal blood concentrations.
ketoconazolecalciumantacidabsorptiongastric phantifungalnizoraltums