1 interaction related to irritability
Levetiracetam (Keppra) commonly causes behavioral side effects including irritability, agitation, anxiety, and mood changes (sometimes called 'Keppra rage'). Several observational studies and case series in both pediatric and veteran populations suggest that adjunctive pyridoxine (vitamin B6) supplementation reduces these behavioral symptoms in roughly 40-50% of patients, though randomized controlled trial data are mixed.