insulin resistance
3 interactions related to insulin resistance
mk-677 + insulin
MK-677 raises growth hormone, and growth hormone reduces the body's sensitivity to insulin. Across multiple controlled trials this shows up as rising fasting blood sugar and rising HbA1c. In a two-year randomised trial, sixteen of forty-three participants taking MK-677 crossed into the impaired fasting glucose range, against two of twenty-two on placebo, and insulin sensitivity fell measurably. A more recent six-month trial saw HbA1c rise significantly, with two of thirteen participants stopping because of high blood sugar. This works directly against what insulin is prescribed to do.
mk-677 + metformin
MK-677 raises growth hormone, and growth hormone reduces the body's sensitivity to insulin. Across multiple controlled trials this shows up as rising fasting blood sugar and rising HbA1c. In a two-year randomised trial, sixteen of forty-three participants taking MK-677 crossed into the impaired fasting glucose range, against two of twenty-two on placebo, and insulin sensitivity fell measurably. A more recent six-month trial saw HbA1c rise significantly, with two of thirteen participants stopping because of high blood sugar. This works directly against what metformin is prescribed to do.
smoking + insulin
Smoking worsens insulin resistance through nicotine-driven catecholamine release, oxidative stress, and inflammation, and slows subcutaneous insulin absorption through vasoconstriction, so people with diabetes who smoke typically need more insulin to reach the same glucose control. Quitting improves insulin sensitivity within days to weeks, so insulin doses often need to come down to avoid hypoglycemia.