inflammation
4 interactions related to inflammation
curcumin + ginger
Curcumin and ginger both inhibit NF-kB and COX-2 signaling, but ginger also independently blocks 5-lipoxygenase and contains gingerols and shogaols that suppress prostaglandin and leukotriene synthesis. A randomized trial of a turmeric-black pepper-ginger combination showed efficacy comparable to naproxen for chronic knee osteoarthritis pain.
omega-3 + curcumin
Omega-3 fatty acids (EPA and DHA) and curcumin both reduce inflammation through complementary pathways — omega-3s alter cell membrane composition and produce specialized pro-resolving mediators, while curcumin directly inhibits NF-kB and inflammatory cytokine signaling.
curcumin + boswellia
Curcumin inhibits NF-kB and dampens COX-2 transcription while boswellic acids (particularly AKBA) selectively block 5-lipoxygenase and leukotriene synthesis. Together they suppress two non-overlapping arms of the inflammatory cascade, giving better symptom relief in osteoarthritis than either alone.
boswellia + omega-3
Boswellic acids inhibit 5-lipoxygenase to block pro-inflammatory leukotrienes, while EPA and DHA from omega-3s reduce arachidonic acid availability and serve as substrates for specialized pro-resolving mediators (resolvins, protectins) that actively turn off inflammation. The two ingredients suppress inflammation at different steps of the same lipid cascade, giving complementary anti-inflammatory coverage.