hypomagnesemia
5 interactions related to hypomagnesemia
hydrochlorothiazide + magnesium
Thiazide diuretics such as hydrochlorothiazide increase urinary magnesium excretion, and a meaningful minority of long-term users become magnesium-depleted. Low magnesium also makes potassium hard to replace and can worsen muscle cramps and heart-rhythm risk.
omeprazole + magnesium
Long-term omeprazole use (typically more than a year, occasionally sooner) can lower body magnesium, likely by impairing active intestinal magnesium transport through the TRPM6/TRPM7 channels. The FDA issued a formal Drug Safety Communication in 2011 warning that prescription proton pump inhibitors can cause hypomagnesemia, with serious cases involving abnormal heart rhythm, muscle spasm (tetany), and seizures.
pantoprazole + magnesium
Pantoprazole, like all proton pump inhibitors (PPIs), is associated with low magnesium (hypomagnesemia) after long-term use, likely by impairing active intestinal magnesium transport. The FDA included pantoprazole in its 2011 Drug Safety Communication on PPI-induced hypomagnesemia, which in severe cases can cause arrhythmia, tetany, and seizures.
furosemide + magnesium
Furosemide blocks the Na-K-2Cl cotransporter in the loop of Henle, which removes the electrical gradient that normally helps the kidney reabsorb magnesium. This can increase urinary magnesium loss, especially with high-dose or prolonged use. In most outpatients the kidney's downstream segments compensate, so clinically meaningful hypomagnesemia is less common with loop diuretics than with thiazides; the effect is more relevant during high-dose IV diuresis, critical illness, or poor intake.
alcohol + magnesium
Alcohol acts as an acute magnesium diuretic, increasing urinary magnesium excretion within hours of intake. Regular and heavy drinking can deplete body magnesium stores through renal wasting combined with reduced intestinal absorption and poor diet, and low magnesium is common in chronic alcohol-use disorder.