hypomagnesemia
5 interactions related to hypomagnesemia
hydrochlorothiazide + magnesium
Thiazide diuretics increase urinary magnesium excretion and roughly 1 in 5 long-term users develop hypomagnesemia. Low magnesium worsens the hypokalemia that thiazides also cause and can perpetuate refractory potassium depletion.
omeprazole + magnesium
Long-term omeprazole use (typically >1 year) is associated with hypomagnesemia, likely via impaired active intestinal magnesium transport through TRPM6/TRPM7 channels. The FDA issued a formal Drug Safety Communication in 2011 warning of serious adverse events including arrhythmia, tetany, and seizures.
pantoprazole + magnesium
Pantoprazole, like all PPIs, is associated with hypomagnesemia after long-term use, likely via impaired active intestinal magnesium transport (TRPM6/TRPM7). The FDA included pantoprazole in its 2011 Drug Safety Communication on PPI-induced hypomagnesemia, which can cause arrhythmia, tetany, and seizures.
furosemide + magnesium
Furosemide inhibits the Na-K-2Cl cotransporter, which abolishes the lumen-positive voltage driving paracellular magnesium reabsorption in the thick ascending limb. Long-term loop diuretic use causes urinary magnesium wasting and hypomagnesemia, which worsens loop-diuretic hypokalemia and increases arrhythmia risk.
alcohol + magnesium
Alcohol acts as an acute magnesium diuretic, dramatically increasing urinary magnesium excretion within hours of intake. Chronic drinking depletes body magnesium stores through this renal wasting combined with reduced intestinal absorption, leading to hypomagnesemia in up to 60 percent of heavy drinkers.