hypericum perforatum
2 interactions related to hypericum perforatum
verapamil + st. john's wort
St. John's wort is a potent inducer of intestinal CYP3A4 and P-glycoprotein. In a controlled study, two weeks of St. John's wort reduced the AUC of R- and S-verapamil by roughly 78-80%, dramatically lowering systemic drug exposure and likely therapeutic effect.
verapamilst johns worthypericum perforatumcyp3a4p-glycoproteincalcium channel blockerherbal interactionenzyme induction
digoxin + st. john's wort
St. John's wort induces intestinal P-glycoprotein, increasing efflux of digoxin and reducing its absorption. Controlled studies show digoxin AUC falls roughly 25% and peak concentrations around 30-36% after two weeks of St. John's wort, potentially producing therapeutic failure in rate control or heart failure management.
digoxinst johns worthypericum perforatump-glycoproteincyp3a4cardiac glycosideherbal interactionenzyme induction