hypericum perforatum
2 interactions related to hypericum perforatum
digoxin + st. john's wort
St. John's wort revs up a gut transporter that digoxin depends on for absorption, so combining them quietly drains digoxin from the bloodstream. Because digoxin has so little room to spare, that drop can leave the drug too weak to control your heart.
digoxinst johns worthypericum perforatump-glycoproteincyp3a4cardiac glycosideherbal interactionenzyme induction
verapamil + st. john's wort
St. John's wort is a potent inducer of intestinal CYP3A4 and P-glycoprotein, the same enzymes that break down verapamil before it reaches the bloodstream. Taking the two together sharply lowers verapamil's systemic exposure and can erase its therapeutic effect on blood pressure, heart rhythm, or migraine prevention.
verapamilst johns worthypericum perforatumcyp3a4p-glycoproteincalcium channel blockerherbal interactionenzyme induction