hydrochlorothiazide
5 interactions related to hydrochlorothiazide
hydrochlorothiazide + calcium
Thiazide diuretics increase renal tubular reabsorption of calcium and reduce urinary calcium excretion, which is therapeutically useful for preventing kidney stones and reducing bone loss. However, this calcium-sparing effect can produce hypercalcemia when combined with high-dose calcium supplements, vitamin D, or in patients with underlying primary hyperparathyroidism.
hydrochlorothiazide + magnesium
Thiazide diuretics increase urinary magnesium excretion and roughly 1 in 5 long-term users develop hypomagnesemia. Low magnesium worsens the hypokalemia that thiazides also cause and can perpetuate refractory potassium depletion.
hydrochlorothiazide + potassium
Hydrochlorothiazide promotes urinary potassium excretion at the distal convoluted tubule and is a leading cause of drug-induced hypokalemia. Many patients still develop low potassium despite supplementation, while some on combination antihypertensives risk the opposite problem if a potassium-sparing agent is added.
alcohol + hydrochlorothiazide
Hydrochlorothiazide and alcohol both lower blood pressure and promote dehydration; combined use causes additive hypotension, dizziness, and orthostatic syncope, especially on standing or in hot weather. The combination also worsens electrolyte loss, particularly potassium and magnesium.
hibiscus tea + hydrochlorothiazide
Hibiscus (Hibiscus sabdariffa) has intrinsic diuretic and antihypertensive activity and animal studies show it increases serum levels of hydrochlorothiazide while reducing its clearance. The combination can produce additive blood pressure lowering and amplified electrolyte loss including hypokalemia.