1 interaction related to hpa-axis
Ashwagandha (Withania somnifera) downregulates the HPA axis and lowers morning cortisol, while reishi (Ganoderma lucidum) provides immunomodulatory beta-glucans and triterpenes that support parasympathetic tone. A 2025 randomized, double-blind, placebo-controlled trial in 499 healthy adults (Pham et al, Current Developments in Nutrition) found that 6 weeks of a reishi + ashwagandha supplement significantly reduced perceived stress versus placebo, without significant adverse events.