herbal supplement
2 interactions related to herbal supplement
alcohol + kava
Kava and alcohol both depress the central nervous system through GABAergic and other mechanisms, producing additive sedation and motor impairment. More importantly, both substances are hepatotoxic, and concurrent use significantly increases the risk of severe liver injury, including cases of fulminant liver failure requiring transplantation.
alcoholkavakava kavahepatotoxicityliver injurycns depressionsedationherbal supplementfda warning
alcohol + valerian
Valerian root acts on GABA-A receptors and may inhibit GABA breakdown, producing sedative effects that are additive with alcohol's CNS depressant effects. The combination produces increased drowsiness, impaired psychomotor performance, and risk of falls, particularly in older adults.
alcoholvalerianvalerian rootsleep aidgabacns depressionsedationherbal supplementanxiety