1 interaction related to hepcidin
Omeprazole reduces absorption of nonheme (plant and supplemental) iron by raising stomach pH, which hinders the conversion of ferric (Fe3+) iron to the absorbable ferrous (Fe2+) form. Population data link long-term proton pump inhibitor (PPI) use with a higher risk of iron deficiency. A second, hormonal mechanism involving hepcidin and ferroportin has been proposed but rests on laboratory and animal work, not human outcomes.
