hair loss
2 interactions related to hair loss
carbamazepine + biotin
Carbamazepine gradually lowers biotin (vitamin B7) status by reducing intestinal absorption, increasing urinary loss, and accelerating breakdown of the vitamin. The effect is biomarker-level and well documented over decades; frank deficiency and serious adult harm are uncommon.
carbamazepinetegretolbiotinvitamin b7anticonvulsantabsorptionhair lossdeficiencyepilepsy
valproate + biotin
Valproate appears to lower biotinidase activity and may impair mitochondrial biotin handling, contributing to subnormal biotin status that has been linked to the drug's characteristic hair thinning and brittle nails. Case reports describe biotin supplementation reversing valproate-related hair loss, though the underlying biotin-status studies are mixed.
valproatevalproic acidbiotinvitamin b7anticonvulsanthair lossalopeciadeficiencybiotinidase