hair loss
2 interactions related to hair loss
carbamazepine + biotin
Carbamazepine reduces biotin status by inhibiting sodium-dependent biotin uptake in the intestine, decreasing renal reabsorption, and accelerating biotin catabolism through enzyme induction; long-term users often have measurably lower plasma biotin and elevated organic-acid markers of biotin insufficiency.
carbamazepinetegretolbiotinvitamin b7anticonvulsantabsorptionhair lossdeficiencyepilepsy
valproate + biotin
Valproate appears to reduce biotinidase activity and impair mitochondrial biotin handling, leading to subnormal biotin status that has been linked to the drug's signature alopecia (hair loss) and brittle nails; biotin supplementation has reversed hair loss in case reports.
valproatevalproic acidbiotinvitamin b7anticonvulsanthair lossalopeciadeficiencybiotinidase