glutathione peroxidase
2 interactions related to glutathione peroxidase
nac + selenium
NAC supplies cysteine, the rate-limiting building block for glutathione synthesis, while selenium is the cofactor built into the glutathione peroxidase enzymes that use glutathione to neutralize peroxides. The two nutrients support the same antioxidant pathway, so on a mechanistic level each helps the other work. Combined clinical benefit beyond that shared pathway is not well demonstrated, and the pairing is low-risk.
vitamin e + selenium
Vitamin E and selenium are complementary antioxidants. Selenium is the cofactor for glutathione peroxidase, which clears lipid peroxides and spares vitamin E, while vitamin E intercepts free radicals in membranes and reduces the demand on the selenium-dependent enzyme. The partnership is well established in animal and mechanistic studies; clinical benefit of the combination in people is more limited.