1 interaction related to ginkgotoxin
Ginkgo biloba induces CYP2C19, the primary enzyme responsible for phenytoin metabolism. A published case report described a fatal breakthrough seizure in a patient on phenytoin and valproate whose autopsy revealed subtherapeutic anticonvulsant levels and self-administration of ginkgo biloba. Ginkgo also has independent pro-convulsant potential at high doses and through ginkgotoxin contamination.