gi bleeding
4 interactions related to gi bleeding
alcohol + naproxen
Naproxen and alcohol combine to substantially increase the risk of stomach bleeding, ulcers, and kidney injury through additive effects on gastric mucosal damage, platelet inhibition, and reduced renal perfusion. Naproxen's longer half-life means the interaction window is more prolonged than with shorter-acting NSAIDs.
alcohol + celecoxib
Celecoxib combined with alcohol increases the risk of gastrointestinal bleeding and ulcers, though somewhat less than non-selective NSAIDs because celecoxib spares COX-1 and has minimal platelet effects. The combination also increases liver enzyme elevations and kidney injury risk through additive effects on hepatic metabolism and renal perfusion.
alcohol + aspirin
Alcohol and aspirin together significantly increase the risk of gastrointestinal bleeding because aspirin irreversibly inhibits platelets for their entire 7-10 day lifespan while alcohol damages the gastric lining and impairs clot formation. The risk is particularly elevated for daily low-dose aspirin users who drink regularly.
alcohol + ibuprofen
Alcohol and ibuprofen each independently irritate the gastric lining and impair platelet function, and together they significantly increase the risk of gastrointestinal bleeding, ulcers, and acute kidney injury. Chronic combined use also accelerates kidney damage through dehydration and reduced renal perfusion.