gastric acid
2 interactions related to gastric acid
omeprazole + vitamin b12
Omeprazole suppresses gastric acid, which is required to cleave vitamin B12 from dietary proteins before it can bind intrinsic factor and be absorbed in the ileum. Long-term use (typically >2 years) is associated with measurably lower serum B12 levels and increased risk of clinical deficiency.
omeprazoleppivitamin b12cobalaminabsorptiondeficiencygastric acidlong-term use
omeprazole + iron
Omeprazole reduces absorption of nonheme (plant and supplemental) iron by raising gastric pH, which prevents the reduction of ferric (Fe3+) to absorbable ferrous (Fe2+) iron. Recent research also shows PPIs upregulate hepcidin and downregulate duodenal ferroportin, directly blocking iron export from enterocytes.
omeprazoleppiironferrous sulfateabsorptionanemiahepcidingastric acid