furosemide
3 interactions related to furosemide
furosemide + potassium
Furosemide is a loop diuretic that blocks the sodium-potassium-chloride cotransporter in the kidney, making it one of the most reliable causes of drug-induced low potassium (hypokalemia). Supplementation or potassium-sparing co-therapy is often needed, but adding potassium on your own — especially alongside ACE inhibitors, ARBs, or kidney impairment — can swing levels too high. The combination should always be guided by blood monitoring rather than self-dosing.
furosemide + magnesium
Furosemide blocks the Na-K-2Cl cotransporter in the loop of Henle, which removes the electrical gradient that normally helps the kidney reabsorb magnesium. This can increase urinary magnesium loss, especially with high-dose or prolonged use. In most outpatients the kidney's downstream segments compensate, so clinically meaningful hypomagnesemia is less common with loop diuretics than with thiazides; the effect is more relevant during high-dose IV diuresis, critical illness, or poor intake.
furosemide + licorice
Glycyrrhizin in licorice inhibits 11-beta-hydroxysteroid dehydrogenase type 2, allowing cortisol to act on mineralocorticoid receptors and driving renal potassium loss. Combined with furosemide, which already wastes potassium, this can add up to a markedly higher risk of significant hypokalemia, worsening edema, raised blood pressure, and arrhythmia.