furanocoumarins
2 interactions related to furanocoumarins
tacrolimus + grapefruit
Grapefruit furanocoumarins irreversibly inhibit intestinal CYP3A4, increasing tacrolimus AUC by roughly 28% and Cmax by up to 73%. Case reports describe trough levels tripling after grapefruit ingestion, producing nephrotoxicity and neurotoxicity.
tacrolimusgrapefruitcyp3a4furanocoumarinstransplantnephrotoxicityfood drug interactionimmunosuppressant
cyclosporine + grapefruit
Grapefruit juice contains furanocoumarins that irreversibly inhibit intestinal CYP3A4, raising cyclosporine bioavailability by 35-60% and increasing the risk of nephrotoxicity, hypertension, and neurotoxicity. The effect can persist for 24 hours or longer after a single glass.
cyclosporinegrapefruitcyp3a4furanocoumarinstransplantnephrotoxicityfood drug interactionimmunosuppressant