1 interaction related to fracture risk
Omeprazole strongly suppresses stomach acid, and calcium carbonate (the most common supplemental form) needs that acid to dissolve and be absorbed efficiently, especially on an empty stomach. Calcium citrate absorbs well regardless of stomach acid. Long-term proton pump inhibitor use is also associated with a modestly increased risk of hip, wrist, and spine fractures, which prompted an FDA labeling change.
