fosamax
2 interactions related to fosamax
alendronate + coffee
Studies cited in the FDA label show coffee (and orange juice) reduce alendronate bioavailability by approximately 60%. Given the drug's already minuscule baseline absorption of ~0.6%, this drop can render the dose therapeutically ineffective.
alendronatecoffeebisphosphonateosteoporosisbioavailabilityabsorptionfosamaxdrug timing
alendronate + calcium
Calcium binds alendronate in the gut and forms an insoluble chelate, drastically reducing absorption of an already poorly bioavailable bisphosphonate (oral bioavailability is only ~0.6%). Co-administration can render the osteoporosis drug clinically ineffective.
alendronatecalciumbisphosphonateosteoporosisabsorptionchelationfosamaxdrug timing