food-drug interaction
7 interactions related to food-drug interaction
oranges + ace inhibitors
Oranges and orange juice are high in potassium (about 240 mg per medium orange, 450-500 mg per cup of juice), and ACE inhibitors reduce aldosterone and renal potassium excretion. Heavy consumption of oranges or orange juice with ACE inhibitors can raise serum potassium, with greater risk in patients with reduced kidney function.
potatoes + ace inhibitors
Potatoes are very high in potassium (a medium baked potato with skin contains about 900 mg), and ACE inhibitors reduce aldosterone-mediated potassium excretion. Regular large servings of potatoes combined with ACE inhibitors can raise serum potassium, particularly in patients with chronic kidney disease, heart failure, or diabetes.
pomelo + simvastatin
Pomelo (Citrus maxima) contains furanocoumarins that irreversibly inhibit intestinal CYP3A4, the enzyme that metabolizes simvastatin during first-pass absorption. With CYP3A4 disabled, simvastatin plasma concentrations rise substantially, increasing the risk of myopathy and rhabdomyolysis.
bananas + spironolactone
Bananas are a high-potassium food (around 422 mg per medium banana), and spironolactone is a potassium-sparing diuretic that reduces renal potassium excretion. Combining high dietary potassium with spironolactone can cause hyperkalemia, which may trigger dangerous cardiac arrhythmias.
coconut water + spironolactone
Coconut water is naturally high in potassium (roughly 600 mg per cup) and is often consumed in large volumes for hydration. Spironolactone is a potassium-sparing diuretic that reduces renal potassium excretion. Regular high-volume coconut water consumption with spironolactone can cause hyperkalemia, including cases reported in the medical literature.
bananas + lisinopril
Lisinopril is an ACE inhibitor that reduces aldosterone and increases serum potassium. Combined with high dietary potassium from bananas and other potassium-rich foods, this can cause hyperkalemia, particularly in patients with reduced kidney function or those also taking potassium-sparing diuretics.
avocado + ace inhibitors
Avocados are a high-potassium food (about 487 mg per half avocado), and ACE inhibitors reduce aldosterone-driven potassium excretion. Frequent large servings of avocado combined with ACE inhibitors can contribute to hyperkalemia, especially in patients with kidney impairment or other potassium-raising medications.