fluoroquinolone
4 interactions related to fluoroquinolone
yogurt + antibiotics
The calcium in yogurt can bind to certain antibiotics — specifically the tetracyclines and fluoroquinolones — in the gut and reduce how much of the drug is absorbed. This is the same chelation interaction seen with milk. Penicillins and macrolides are not meaningfully affected. The fix is timing: take these antibiotics with water and keep yogurt and other calcium-rich foods a couple of hours apart from the dose.
caffeine + ciprofloxacin
Ciprofloxacin inhibits the liver enzyme CYP1A2, which is the main pathway that clears caffeine. As a result, caffeine is broken down more slowly, its blood levels stay higher for longer, and its stimulant effects are amplified and prolonged while you are on the antibiotic.
levofloxacin + calcium
Calcium binds (chelates) levofloxacin in the gastrointestinal tract, modestly lowering the antibiotic's peak blood level. Total drug exposure over the dosing interval is largely preserved, so the effect is smaller than with iron, magnesium, or aluminum. Separating the doses by a couple of hours avoids the interaction.
coffee + ciprofloxacin
Ciprofloxacin inhibits CYP1A2, the liver enzyme that clears caffeine, slowing caffeine metabolism so a normal amount of coffee produces higher, longer-lasting caffeine levels and stronger stimulant effects.