fluoroquinolone
4 interactions related to fluoroquinolone
yogurt + antibiotics
Yogurt's calcium content can reduce the absorption of tetracycline and fluoroquinolone antibiotics through chelation, and antibiotics may also kill the live probiotic bacteria in yogurt. Taking yogurt and antibiotics simultaneously reduces the effectiveness of both.
caffeine + ciprofloxacin
Ciprofloxacin is a potent CYP1A2 inhibitor. Co-administration increases caffeine's area-under-the-curve by 50-100% and prolongs its half-life, producing exaggerated central nervous system and cardiovascular stimulation.
levofloxacin + calcium
Calcium chelates levofloxacin in the gastrointestinal tract, reducing peak serum concentrations by 20 to 30 percent. While the area under the curve is less affected than with older fluoroquinolones, the drop in peak concentration can matter for organisms with MICs close to the breakpoint.
coffee + ciprofloxacin
Ciprofloxacin is a potent inhibitor of CYP1A2, the enzyme that metabolizes caffeine. Co-administration can reduce caffeine clearance by 30% to 50% and prolong its half-life, leading to higher plasma caffeine levels, jitteriness, insomnia, palpitations, tremor, and (rarely) seizures.