ferrous sulfate
7 interactions related to ferrous sulfate
levothyroxine + iron
When taken at the same time, iron can reduce how much levothyroxine your body absorbs by forming a poorly soluble complex in the gut, which can blunt the effect of your thyroid medication and raise TSH.
doxycycline + iron
Iron forms an insoluble chelate complex with doxycycline in the gut, sharply reducing absorption of the antibiotic. In controlled human studies, ferrous sulfate taken together with doxycycline cut serum antibiotic levels substantially, which can undermine treatment.
vitamin c + iron
Vitamin c enhances absorption of non-heme iron from supplements and plant foods, a beneficial nutrient synergy, though the real-world benefit across a full diet is usually modest.
calcium + iron
Calcium can reduce the absorption of iron when the two are taken together, with the effect most pronounced for non-heme iron from supplements and plant foods.
iron + zinc
High-dose iron and zinc supplements can compete for absorption in the small intestine when taken together, especially in solution on an empty stomach, potentially reducing the effectiveness of one or both minerals. The competition is minimal when the minerals are taken with food or hours apart, or at ordinary dietary amounts.
black tea + iron
Black tea is rich in polyphenols (tannins) that bind iron in the digestive tract. When the two are taken together, less of the iron your body needs gets absorbed.
omeprazole + iron
Omeprazole reduces absorption of nonheme (plant and supplemental) iron by raising stomach pH, which hinders the conversion of ferric (Fe3+) iron to the absorbable ferrous (Fe2+) form. Population data link long-term proton pump inhibitor (PPI) use with a higher risk of iron deficiency. A second, hormonal mechanism involving hepcidin and ferroportin has been proposed but rests on laboratory and animal work, not human outcomes.