fda warning
6 interactions related to fda warning
alcohol + kava
Kava and alcohol both depress the central nervous system through GABAergic and other mechanisms, producing additive sedation and motor impairment. More importantly, both substances are hepatotoxic, and concurrent use significantly increases the risk of severe liver injury, including cases of fulminant liver failure requiring transplantation.
omeprazole + magnesium
Long-term omeprazole use (typically >1 year) is associated with hypomagnesemia, likely via impaired active intestinal magnesium transport through TRPM6/TRPM7 channels. The FDA issued a formal Drug Safety Communication in 2011 warning of serious adverse events including arrhythmia, tetany, and seizures.
pantoprazole + magnesium
Pantoprazole, like all PPIs, is associated with hypomagnesemia after long-term use, likely via impaired active intestinal magnesium transport (TRPM6/TRPM7). The FDA included pantoprazole in its 2011 Drug Safety Communication on PPI-induced hypomagnesemia, which can cause arrhythmia, tetany, and seizures.
alcohol + pregabalin
Pregabalin (Lyrica) and alcohol are both central nervous system depressants with additive effects on sedation, coordination, and respiratory drive. The FDA's 2019 Drug Safety Communication warned that pregabalin can cause life-threatening respiratory depression when combined with CNS depressants such as alcohol, particularly with opioids or in patients with lung disease.
biotin + troponin test
High-dose biotin (vitamin B7) interferes with biotin-streptavidin-based immunoassays used to measure cardiac troponin, producing falsely low results that can mask an evolving heart attack. The FDA has received reports of patient harm, including one death linked to a missed myocardial infarction diagnosis caused by biotin-altered troponin readings.
alcohol + gabapentin
Gabapentin and alcohol are both central nervous system depressants. The FDA issued a 2019 Drug Safety Communication warning that gabapentin can cause serious, potentially fatal respiratory depression when combined with CNS depressants including alcohol, particularly in older adults and patients with respiratory disease.