fda warning
6 interactions related to fda warning
alcohol + kava
Kava and alcohol both depress the central nervous system, producing additive sedation and impaired coordination. More importantly, both are hepatotoxic: kava is a well-documented cause of severe and occasionally fatal liver injury, and alcohol adds a second liver stressor.
omeprazole + magnesium
Long-term omeprazole use (typically more than a year, occasionally sooner) can lower body magnesium, likely by impairing active intestinal magnesium transport through the TRPM6/TRPM7 channels. The FDA issued a formal Drug Safety Communication in 2011 warning that prescription proton pump inhibitors can cause hypomagnesemia, with serious cases involving abnormal heart rhythm, muscle spasm (tetany), and seizures.
pantoprazole + magnesium
Pantoprazole, like all proton pump inhibitors (PPIs), is associated with low magnesium (hypomagnesemia) after long-term use, likely by impairing active intestinal magnesium transport. The FDA included pantoprazole in its 2011 Drug Safety Communication on PPI-induced hypomagnesemia, which in severe cases can cause arrhythmia, tetany, and seizures.
alcohol + pregabalin
Pregabalin and alcohol are both central nervous system depressants. Taken together their sedative effects add up, increasing drowsiness, dizziness, and impaired coordination, and at the serious end can cause life-threatening respiratory depression — a risk highlighted by FDA and MHRA safety warnings.
biotin + troponin test
High-dose biotin (vitamin B7) can interfere with the biotin-streptavidin chemistry used in many cardiac troponin immunoassays, potentially producing a falsely low result. The FDA has warned about this since 2017, but real-world data suggest clinically meaningful interference is uncommon at the doses found in typical over-the-counter supplements. The practical risk is real but narrower than once feared.
alcohol + gabapentin
Gabapentin and alcohol are both central nervous system depressants. Combining them increases drowsiness, dizziness, impaired coordination, and the risk of serious, potentially life-threatening respiratory depression, especially in older adults and people with lung disease, sleep apnea, kidney impairment, or who take opioids or other sedatives.