fda label warning

amiodarone + grapefruit

Grapefruit and grapefruit juice inhibit intestinal CYP3A4, the enzyme that metabolizes oral amiodarone. This raises amiodarone blood levels and largely shuts down production of its active metabolite, N-desethylamiodarone. The FDA-approved Pacerone label explicitly states grapefruit juice should not be consumed during oral amiodarone treatment.